IL-10- and TGFβ-mediated Th9 Responses in a Human Helminth Infection

IL-10- and TGFβ-mediated Th9 Responses in a Human Helminth Infection

BACKGROUND Th9 cells are a subset of CD4+ T cells that express the protoypical cytokine, IL-9. Th9 cells are known to effect protective immunity in animal models of intestinal helminth infections. However, the role of Th9 cells in human intestinal helminth infections has never been examined. METHODOLOGY To examine the role of Th9 cells in Strongyloidis stercoralis (Ss), a common intestinal he...

Eosinophil-mediated tissue inflammatory responses in helminth infection.

Eosinophilic leukocytes function in host protection against parasitic worms. In turn, helminthic parasites harbor specific molecules to evade or paralyze eosinophil-associated host immune responses; these molecules facilitate the migration and survival of parasitic helminths in vivo. This competition between eosinophil and worm leads to stable equilibria between them. An understanding of such d...

Induction of IL-10-Producing Macrophages Allergic and Inflammatory Responses by A Helminth Immunomodulator Reduces

Polymorphisms in the IFNγ, IL-10, and TGFβ Genes May Be Associated with HIV-1 Infection

OBJECTIVE This study investigated possible associations between the TNFα-308G/A, IFN+874A/T, IL-6-174C/G, IL-10-1082A/G, and TGFβ-509C/T polymorphisms with HIV-1 infection, in addition to correlation of the polymorphisms with clinical markers of AIDS progression, such as levels of CD4+/CD8+ T lymphocytes and plasma viral load. METHODS A total of 216 individuals who were infected with HIV-1 an...

The role of interleukin-10 (IL-10) in IL-15-mediated T-cell responses.

Interleukin-15 (IL-15) is a potent T-cell stimulating factor, which has recently been used for pre-clinical in vivo immunotherapy. Here, the IL-15 effect on CD3-stimulated peripheral human T cells was investigated. IL-15 induced a significant T-cell proliferation and upregulated CD25 expression. IL-15 significantly enhanced T-cell production of interferon-gamma (IFN-gamma), tumor necrosis facto...